Treatment of the acute ulcerative necrotizing gingivitis with OLEOZON¨.
Mart’nez M., MenŽndez S. and Castillo A. (Cuba)

The ulcerative necrotizing gingivitis is a painful and destructive illness of the gingiva, characterized by inflammation, redness, swelling and tendency to bleed. The aim of this study is to evaluate the efficacy of OLEOZON¨ (sunflower ozonized oil) in the treatment of ulcerative necrotizing gingivitis in an acute phase. A clinical random trial, phase III, simple blind test, was carried out in 48 patients, where OLEOZON¨ was compared with a control group. The odontologist didnŐt know to what group belonged each patient. Experimental group: 24 patients treated with OLEOZON¨, topically, 3 times per day, during 7 days. Control group: patients treated, locally, with a solution of sodium perborate, 3 times per day, during 7 days. The healing criteria established were: disappearance of the lesions, pain, bleeding and pseudomembrane. The evaluations were made at the 3rd and 7th days of beginning the treatment. The results demonstrated that at the end of the treatment, in the experimental group 75 % of patients cured in comparison with the control group (29.2 %), with significant differences (p = 0.01) between both groups. Also, in the experimental group the disappearance of symptoms was achieved more rapidly in comparison with control group. No side effects were observed. It was demonstrated that OLEOZON¨ is more effective in comparison with sodium perborate in the treatment of patients with acute ulcerative necrotizing gingivitis, being an appropriate therapeutic option for this disease.

Use of OLEOZON¨ in vaginal monilia treatment.
El’as-Calles B., Savigne M.E. and Sayoux C. (Cuba)

Monilia or Candida albicans mycosis is a yeast vaginal infection. OLEOZON¨ (ozonized sunflower oil) has a broad anti microbial spectrum, registered as antifungal product in Cuba. In vitro studies, it has shown a great efficacy against yeasts. Taking into account its germicidal properties, a group of 483 women (31 - 45 years old), suffering of vaginal monilia, confirmed by clinical symptoms and microbiological tests, were treated with OLEOZON¨. A cycle of daily vaginal embrocation, during 10 days, was employed. If the treatment was not effective, a second cycle of treatment was applied. The results demonstrated that 81.2 % of the patients showed no evidence of clinical symptoms and 82.3 % of cases showed negative microbiological tests after a first cycle treatment. The use of a second cycle, showed no evidence of clinical symptoms in 84.3 % of cases and negative microbiological tests in 87.2 % of patients.

Generalization of the use of OLEOZON¨ in the treatment of tinea pedis. Preliminary study
Falc—n L., Daniel R.D. and MenŽndez S. (Cuba)

Tinea pedis is a frequently occurring disease which produces different tissue lesions as desquamation, maceration and pruritus. This clinical syndrome is often resistant to treatment and frequently relapses occur. Ozonized sunflower oil, OLEOZON¨, has a remarkable germicidal action. In a preceding paper, it has been demonstrated the efficacy of OLEOZON¨ in patients with tinea pedis, in a phase III clinical trial, using Nizoral as control group. The aim of this study was to generalize the use of OLEOZON¨ in patients with tinea pedis. Four hundred and forty three, in- and out- patients, from "Dr Carlos J. Finlay" Military Hospital were treated topically (once a day) with OLEOZON¨, during 6 weeks. The results demonstrated that 381 patients (86 %) were healed and the most effective results were found in scaled and macerated clinical forms. Slight side effects were only seen in three patients.

OLEOZON¨: An effective treatment in the management of pyodermitis.
Daniel R.D., Falc&oacuten; L., Moya S., Garbayo E. and MenŽndez S. (Cuba)

Pyoderma is an acute, inflammatory, purulent disease. Taking into account the germicidal power of ozonized sunflower oil (OLEOZON¨), we decided to study the efficacy of it in the treatment of pyoderma and to compare it with Neobatin, as conventional drug. A sample of 1098 out-p atients, with clinical and bacteriological diagnosis of pyoderma, was included in this study. The sample was divided at random into two groups: OLEOZON¨ group and control group, using Neobatin ointment treatment. It was indicated, in both groups, the use of physiological saline compress, twenty minutes before topical application of the specific treatment, in order to remove any crust. Treatments were applied twice daily, during ten days. The results indicated that 90.1 % of the OLEOZON¨ treated patients and 81.6 % of the Neobatin ointment treated patients were negative in the bacteriological test, with statistical significant differences between groups. We concluded that OLEOZON¨ is an effective treatment in the management of pyoderma.

Application of OLEOZON¨ in vulvovaginitis.
Rubio R., El’-Calles B., Favier M., Castellanos G. and Lescaille E. (Cuba)

The aim of this study is to evaluate the efficacy of OLEOZON¨ in patients with vulvovaginitis. Three hundred fifty women were treated with vaginal embrocations of OLEOZON¨, once a day, during 10 days. Microbiological vaginal exams were performed at the beginning and at the end of the treatment. The women age group more affected was 25 - 34 years, and all were workers. Candida albicans was the most frequent microorganism present in this study. Leucorrhea was the symptom more frequent and it disappeared since the 3rd day of treatment, as well as pruritus. The evaluation criteria were disappearance of signs and simptoms and a negative microbiological result. At the end of the treatment, 95 % of patients cured. OLEOZON¨ can be a good medication for the treatment of vulvovaginitis.

Evaluation of therapeutic properties of OLEOZON¨ in the treatment of women with Human Papilloma Virus (HPV) uteri cervix infection.
R’os M.A., Aguilar O., Torres A., Hern‡ndez M., MenŽndez S. and Amig— M. (Cuba)

HPV is associated with cervical cancer and preceding lesions. Cervical cancer is the second most common malignant tumor in the world, although its tendency is to occupy a first place in some geographic zones, such as Central and South America and the Caribbean region. In spite of several studies made worldwide to establish effective therapeutics against HPV infection, there isn't consensus about this. Now there are two different treatments for HPV infections. The first is based in lesion destruction by mean of chemicals or surgical methods, but they can't eliminate viral infection. The second one is based in viral elimination with antiviral agents. The ozonized sunflower oil (OLEOZON¨) has shown antiviral activity in the treatment of viral infections such as Herpes virus. Our main aim in this study was to evaluate the therapeutic efficacy of this product in HPV infected women. To develop this study we selected 12 women with NIC I, associated with HPV and condiloma acuminate lesions. OLEOZON¨ was applied daily, in the uteri cervix of each patient, during 20 days. Cytological, histological (in some cases) and colposcopic examination were made to each patient before and after the treatment. Two of the twelve left the treatment. From the rest, eight (80 %) women showed total clinical and cytological regression of lesions. Viral persistence was observed in two (20 %) patients. In some cases, total elimination of vaginal secretion, was observed after the treatment. Side effects due to the OLEOZON¨ were not observed in any case.