The efficiency of ozone therapy in complex treatment of patients with oncogynecological diseases.
Kontorschikova E., Kontorschikova C., Novikov V., Kryzhanova M., Kachalina T. and Grechkanev G. (Russia)

This work presents the ozone therapy results in patients with ovary and uterus cancer (with dissemination), after nonradical surgical intervention. All the patients were undergoing chemotherapy according to individual programme. Besides clinical examination, to all the patients were measured: lipid peroxidation in blood serum according to the chemiluminescence index, primary (dien conjugates), secondary (trien conjugates) and final (Shiff bases) products and general antioxidant activity. To assess the immune status the mononuclear cell of peripheral blood were immunophenotyped regarding the quantity of CD4, CD8, CD16, CD22, CD25, CD71, CD38, CD95, HLA 1, HLA DR. Also, the activity of cellular and humoral immunity, cells capacity for adhesion and apoptosis were determined. All the patients showed a depression in lipid peroxidation processes, antioxidant activity and immune status index. Taking into consideration the capacity of low ozone concentration to improve the immunity and lipid peroxidation, ozone was used in these patients. Ozone therapy was applied, daily, by rectal insufflations, with an ozone concentration of 2000 g/L of gas mixture, cycle of treatment of 5 - 7 days, with a break for a day of chemotherapy. The clinical effect could be seen in the improvement of appetite, better sleep, reduction of nausea and weakness. Initial laboratory results demonstrated the increase in total antioxidant blood activity. The lipid peroxidation and immune status indexes changed according to the individual treatment of chemotherapy and initial conditions of the patients. Preliminary conclusions can be done on the expediency of ozone therapy in the treatment of chemotherapy complications in patients with oncogynecologycal pathology.